Diabetic Kidney Disease Study

Diabetic patients in Connecticut should be aware of the results of a study conducted by researchers at the Icahn School of Medicine at Mount Sinai. The study, which examined the kidney’s glomerulus, showed that there are biological pathways involved in diabetic kidney disease that may be used to design early detection tests and targeted treatments.

It was revealed that oxidative stress that occurs within a certain group of kidney cells can inhibit how well a kidney can filter waste products out of the blood and create urine. However, the blockage of a cellular receptor can lessen that stress reaction. This was demonstrated in tests on mice who were genetically predisposed to have diabetic kidney failure.

Three different cell types that interact inside of the glomerulus were examined using two sets of mice, one of which developed diabetic kidney disease naturally and the other which had a natural resistance to the disorder. The researchers found that the endothelial cells in the mice prone to kidney disease were affected, causing the mitochondria to produce excessive amounts of reactive oxygen species, which can harm cell proteins and DNA. This weakens the glomerulus, which results in the kidney shedding necessary body proteins and eventually failing.

The National Kidney Foundation states that the kidneys of nearly 30 percent of patients with juvenile onset, or type 1, diabetes and 10 to 40 percent of patients with adult onset, or type 2, diabetes will ultimately fail. When this takes place, the patients will have to undergo dialysis treatment or a kidney transplantation.

Patients who receive a misdiagnosis that results in delayed treatment or the spreading of a disease may have legal recourse. An attorney may file a lawsuit against the at-fault health care professionals in order to obtain financial compensation on behalf of the client.